RPH3A and GCH1

Number of citations of the paper that reports this interaction (PubMedID 7802677)
9

Data Source:
HPRD (in vivo)

		RPH3A	GCH1
Description		rabphilin 3A	GTP cyclohydrolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Synaptic Vesicle Extrinsic Component Of Membrane Secretory Granule Synaptic Vesicle Membrane Protein-containing Complex Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Selenium Binding Small GTPase Binding Phosphate Ion Binding Protein-containing Complex Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Spontaneous Neurotransmitter Secretion	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases
GWAS		Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Chloride levels ( 29403010) Coronary artery disease ( 32469254) Epilepsy ( 33913524) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Low density lipoprotein cholesterol levels ( 32154731 29403010) Low HDL-cholesterol levels ( 31006500) Platelet count ( 22139419) Serum uric acid levels ( 32514006) Spleen volume ( 34128465) Urate levels ( 31578528)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		13 interacting genes: ADD2 CASK GCH1 IFT81 MYO5A NRXN1 RAB15 RAB27A RAB27B RAB3A RAB3B RAB8A YWHAH	25 interacting genes: AHSA1 ATP1B1 ATP6V1A BDH1 CDC37 CHMP4A CNRIP1 GCHFR GIT2 GPATCH2L HNRNPA1 HSPA8 MPPED2 OAZ1 RAB26 RER1 RLF RND3 RPH3A SH3GL2 SP3 TNIP2 TNPO2 TNPO3 YWHAZ
Entrez ID		22895	2643
HPRD ID		15273	02573
Ensembl ID		ENSG00000089169	ENSG00000131979
Uniprot IDs		A0A024RBK6 Q9Y2J0	A0A024R642 P30793 Q8IZH9
PDB IDs			1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89
Enriched GO Terms of Interacting Partners?
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