CCDC125 and PKP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CCDC125	PKP2
Description		coiled-coil domain containing 125	plakophilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	Molecular_function Protein Binding Identical Protein Binding	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Negative Regulation Of Rho Protein Signal Transduction Activation Of GTPase Activity Negative Regulation Of Cell Motility	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 32201043 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		64 interacting genes: BMP7 C1orf109 C21orf58 C22orf15 C4orf45 CCNG1 CDC23 CDK18 CEP95 EIF3D FAM107A FAM161A FAM161B FAM214B FAM47B FLYWCH1 GAS8 GEM HAPLN2 HDAC4 KAT5 KIF9 KRTAP13-2 LCE2C MYH1 NEBL NSD1 NSMF OTOS PKP2 PRPF3 PTPA RAB2A RIPOR3 SFN SNW1 STX11 TCHP TEAD4 TRIM14 TSGA10IP UACA YWHAE YWHAH YWHAQ YWHAZ ZFP1 ZFYVE26 ZNF165 ZNF230 ZNF250 ZNF32 ZNF337 ZNF343 ZNF417 ZNF436 ZNF552 ZNF557 ZNF564 ZNF587 ZNF764 ZNF792 ZNF837 ZNF883	45 interacting genes: ACTN3 AKAP9 ARMC8 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTNNB1 DDX11 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 ITPR2 JUP KDM5A KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 ROPN1 SINHCAF SMAD9 SPTA1 TEKT4 YWHAG
Entrez ID		202243	5318
HPRD ID		13774	04177
Ensembl ID		ENSG00000183323	ENSG00000057294
Uniprot IDs		B4DSR1 Q2HJ12 Q86Z20	Q99959
PDB IDs			3TT9
Enriched GO Terms of Interacting Partners?
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