EIF4B and IPO13

		EIF4B	IPO13
Description		eukaryotic translation initiation factor 4B	importin 13
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Dendrite Neuronal Cell Body Postsynapse	Nucleus Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding	Protein Binding Small GTPase Binding
	Biological Process	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly	Protein Import Into Nucleus
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
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Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		19 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E IPO13 LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11	28 interacting genes: ALX1 ARX CDK1 CRX EIF1AX EIF2B3 EIF3I EIF4B GK HMBOX1 KDM4A MAGOH MAST2 NPSR1 NUP50 PAX3 PAX6 PBX4 PIK3R3 PITX1 PPFIA2 PPIH PREX1 PSMA1 RAN RBM8A RPL5 UBE2I
Entrez ID		1975	9670
HPRD ID		04892	13742
Ensembl ID		ENSG00000063046	ENSG00000117408
Uniprot IDs		B4DRM3 E7EX17 P23588 Q7Z5Y0	O94829
PDB IDs		1WI8 2J76 6FEC	2X19 2XWU 3ZJY
Enriched GO Terms of Interacting Partners?
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