IPO13 and PREX1

		IPO13	PREX1
Description		importin 13	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol Plasma Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding
	Biological Process	Protein Import Into Nucleus	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Neutrophil Activation Positive Regulation Of GTPase Activity Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026)	Colorectal cancer ( 30529582 26151821 31826910) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Diastolic blood pressure ( 28135244 27841878 27618447) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple myeloma ( 27363682) Nephrotic syndrome (acquired) ( 21441931) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ALX1 ARX CDK1 CRX EIF1AX EIF2B3 EIF3I EIF4B GK HMBOX1 KDM4A MAGOH MAST2 NPSR1 NUP50 PAX3 PAX6 PBX4 PIK3R3 PITX1 PPFIA2 PPIH PREX1 PSMA1 RAN RBM8A RPL5 UBE2I	7 interacting genes: IPO13 ITSN1 MTOR NCDN PPP1CA RAC1 RHOA
Entrez ID		9670	57580
HPRD ID		13742	06066
Ensembl ID		ENSG00000117408	ENSG00000124126
Uniprot IDs		O94829	Q8TCU6
PDB IDs		2X19 2XWU 3ZJY	3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1 6PCV 6VSK
Enriched GO Terms of Interacting Partners?
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