EIF4B

Description		eukaryotic translation initiation factor 4B
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Dendrite Neuronal Cell Body Postsynapse
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding
	Biological Process	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)
Interacting Genes		19 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E IPO13 LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11
Entrez ID		1975
HPRD ID		04892
Ensembl ID		ENSG00000063046
Uniprot IDs		B4DRM3 E7EX17 P23588 Q7Z5Y0
PDB IDs		1WI8 2J76 6FEC
Enriched GO Terms of Interacting Partners?
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