EIF4B and RPS6KB1

Number of citations of the paper that reports this interaction (PubMedID 16763566)
190

Data Source:
HPRD (in vitro, in vivo)

		EIF4B	RPS6KB1
Description		eukaryotic translation initiation factor 4B	ribosomal protein S6 kinase B1
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Dendrite Neuronal Cell Body Postsynapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuron Projection Synapse
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly	G1/S Transition Of Mitotic Cell Cycle Apoptotic Process Signal Transduction Peptidyl-serine Phosphorylation Response To Nutrient Levels TOR Signaling Cellular Response To Insulin Stimulus Negative Regulation Of Apoptotic Process Long-chain Fatty Acid Import Into Cell Positive Regulation Of Translation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	mTORC1-mediated signalling
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)	Body shape index ( 34021172) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Obesity-related traits ( 23251661) Triglycerides ( 30275531)
Interacting Genes		19 interacting genes: ACD CASP3 CSNK2A1 EIF3A EIF4E IPO13 LAMTOR5 LINC01554 PABPC1 PAK2 POT1 RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11	62 interacting genes: ACTA1 AKT1 APP BTK CDC42 CDK1 CLEC3B COASY CSNK2A1 CSNK2B CYB5R3 DEPTOR DPPA4 EEF2K EIF3B EIF3F EIF4B EIF4EBP1 EP300 FBXO7 GDI2P1 GRIA1 HTT IRS1 KAT2B KIR3DL1 LYN MAPK1 MAPK3 MAPK8 MAPK9 MAPT MARK2 MTOR MXD1 NCBP1 NEDD4 NEK6 NR1I2 PDK1 PDPK1 PIK3CA PIN1 PIP4K2A POLDIP3 PPP1R9A PPP1R9B PPP2CA RAC1 RBX1 RHEB RPS6 RPTOR SRC STK11 SYK TBK1 TERT TRAF4 URI1 USP11 XPO1
Entrez ID		1975	6198
HPRD ID		04892	10202
Ensembl ID		ENSG00000063046	ENSG00000108443
Uniprot IDs		B4DRM3 E7EX17 P23588 Q7Z5Y0	P23443
PDB IDs		1WI8 2J76 6FEC	3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46 4RLO 4RLP 5WBH 5WBK
Enriched GO Terms of Interacting Partners?
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