SGSM2 and RGMA

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SGSM2	RGMA
Description		small G protein signaling modulator 2	repulsive guidance molecule BMP co-receptor a
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Melanosome	Endoplasmic Reticulum Plasma Membrane Cell Surface Anchored Component Of Membrane Neuron Projection
	Molecular Function	GTPase Activator Activity Small GTPase Binding	Protein Binding Coreceptor Activity Transferrin Receptor Binding
	Biological Process	Intracellular Protein Transport Late Endosome To Golgi Transport Positive Regulation Of GTPase Activity Activation Of GTPase Activity	Neural Tube Closure Positive Regulation Of Neuron Projection Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Neuron Projection Development Positive Regulation Of GTPase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Receptor Binding
Pathways			Netrin-1 signaling
Drugs
Diseases
GWAS		Aortic root size ( 19584346) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Fasting blood proinsulin levels ( 23263489) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Proinsulin levels ( 21873549) Schizophrenia ( 25056061)	Blood protein levels ( 30072576 29875488) Copper levels ( 26025379) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Opioid dependence ( 29478698) Overweight status ( 25133637) Periodontitis (CDC/AAP) ( 24024966) Refractive error ( 32231278) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498) Type 1 diabetes nephropathy ( 23028342) Type 2 diabetes ( 32499647)
Interacting Genes		20 interacting genes: AFP CA12 CELSR3 CHD3 EGFR FNBP1L GDPD2 ILF2 KHDRBS3 MPP1 MTDH PNO1 PTN RAB2A RAB2B RAB3A RAB3B RAB9B RGMA RPS25	5 interacting genes: CRTC3 PPP1R16A SGSM2 TERF2IP TP53BP2
Entrez ID		9905	56963
HPRD ID		15284	09560
Ensembl ID		ENSG00000141258	ENSG00000182175
Uniprot IDs		B9A6J3 O43147	A0A0A0MTQ4 Q96B86
PDB IDs			4UHY 6Z3G
Enriched GO Terms of Interacting Partners?
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