SERPINB2 and IRF3

Number of citations of the paper that reports this interaction (PubMedID 12883638)
1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SERPINB2	IRF3
Description		serpin family B member 2	interferon regulatory factor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity Wound Healing Fibrinolysis Negative Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cellular Response To DNA Damage Stimulus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death Cellular Response To Virus
Pathways		Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	ISG15 antiviral mechanism IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		Urokinase Tenecteplase Lanoteplase
Diseases
GWAS		Asthma ( 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Hen's egg allergy ( 29051540) Hip circumference adjusted for BMI ( 28552196) Systolic blood pressure ( 29208002)	Autoimmune thyroid disease ( 32581359) Schizophrenia ( 29483656) Vitiligo ( 27723757)
Interacting Genes		9 interacting genes: APP CDC42 DCC IRF3 PLAU PRPF8 PSMB1 RB1 UBE3A	33 interacting genes: CREBBP EP300 EWSR1 FBXO7 GRIP1 HERC5 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS OGT PEX19 PIAS4 PPIB PRDX1 PSMD14 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70 TRIM26 TRIM55 TRIM63 UFL1
Entrez ID		5055	3661
HPRD ID		01420	04769
Ensembl ID		ENSG00000197632	ENSG00000126456
Uniprot IDs		P05120	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653
PDB IDs		1BY7 1JRR 2ARQ 2ARR	1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 5JEJ 5JEK 5JEL 5JEM 5JEO 5JER 6SIV 6SJA 7JFL
Enriched GO Terms of Interacting Partners?
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