GIT1 and RGS2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		GIT1	RGS2
Description		GIT ArfGAP 1	regulator of G protein signaling 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Centrosome Cytosol Focal Adhesion Postsynaptic Density Membrane Lamellipodium Calyx Of Held Mitotic Spindle Pole Postsynapse	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	GTPase Activator Activity Protein Binding Gamma-tubulin Binding Protein-containing Complex Binding Metal Ion Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Regulation Of Catalytic Activity Motor Learning Cellular Response To Lipopolysaccharide Positive Regulation Of Microtubule Nucleation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis	Response To Amphetamine Cell Cycle G Protein-coupled Receptor Signaling Pathway Spermatogenesis Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Ovulation Negative Regulation Of MAP Kinase Activity Negative Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		Ephrin signaling Ephrin signaling CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle Activation of RAC1 downstream of NMDARs	G alpha (q) signalling events
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		54 interacting genes: ARHGEF6 ARHGEF7 B9D1 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GPAA1 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	62 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A SUN2 TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		28964	5997
HPRD ID		06577	02917
Ensembl ID		ENSG00000108262	ENSG00000116741
Uniprot IDs		Q59FC3 Q9Y2X7	A0A024R939 P41220
PDB IDs			2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?
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