CYP2A6 and POR

Number of citations of the paper that reports this interaction (PubMedID 15680923)
23

Data Source:
BioGRID (pull down, pull down)

		CYP2A6	POR
Description		cytochrome P450 family 2 subfamily A member 6	cytochrome p450 oxidoreductase
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Iron Ion Binding Coumarin 7-hydroxylase Activity Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Heme Binding	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Nitric Oxide Dioxygenase Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Coumarin Catabolic Process	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Xenobiotic Metabolic Process Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Internal Peptidyl-lysine Acetylation Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Monooxygenase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Negative Regulation Of Lipase Activity Demethylation Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Organofluorine Metabolic Process
Pathways		Xenobiotics CYP2E1 reactions	Cytochrome P450 - arranged by substrate type
Drugs		Coumarin N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE 4,4'-DIPYRIDYL DISULFIDE	Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33339817) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood protein levels ( 28240269) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872) Chronic obstructive pulmonary disease ( 22080838 28166215) Chronotype ( 30696823) Coffee consumption ( 31046077) Liver enzyme levels (alanine transaminase) ( 33972514) Local histogram emphysema pattern ( 25006744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 33144568) Nicotine metabolite ratio in current smokers ( 27488534 28921760 26407342) Non-small cell lung cancer ( 31326317) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum alkaline phosphatase levels ( 33547301 33339817) Smoking behavior ( 23049750 20418888 20418890) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 31089300 30617275 30679032) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Squamous cell lung carcinoma ( 28604730) Urinary sodium excretion ( 31409800)	Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption ( 31959922 31046077 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		2 interacting genes: CYB5A POR	21 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 EHMT2 FANCC HMOX1 LINC01554 PSPHP1 RABEPK RPS4X SIN3B SLC39A2 STAT1 TGFBI XRCC6
Entrez ID		1548	5447
HPRD ID		00420	00485
Ensembl ID		ENSG00000255974
Uniprot IDs		P11509	P16435
PDB IDs		1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ 4RUI	1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6
Enriched GO Terms of Interacting Partners?
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