CYP2A6

Description		cytochrome P450 family 2 subfamily A member 6
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Intracellular Membrane-bounded Organelle
	Molecular Function	Iron Ion Binding Coumarin 7-hydroxylase Activity Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Heme Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Coumarin Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Coumarin Catabolic Process
Pathways		Xenobiotics CYP2E1 reactions
Drugs		Coumarin N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE N-METHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE (5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE 4,4'-DIPYRIDYL DISULFIDE
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33339817) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood protein levels ( 28240269) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872) Chronic obstructive pulmonary disease ( 22080838 28166215) Chronotype ( 30696823) Coffee consumption ( 31046077) Liver enzyme levels (alanine transaminase) ( 33972514) Local histogram emphysema pattern ( 25006744) Low density lipoprotein cholesterol levels ( 32154731) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 33144568) Nicotine metabolite ratio in current smokers ( 27488534 28921760 26407342) Non-small cell lung cancer ( 31326317) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum alkaline phosphatase levels ( 33547301 33339817) Smoking behavior ( 23049750 20418888 20418890) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking behaviour (cigarettes smoked per day) ( 31089300 30617275 30679032) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Squamous cell lung carcinoma ( 28604730) Urinary sodium excretion ( 31409800)
Interacting Genes		2 interacting genes: CYB5A POR
Entrez ID		1548
HPRD ID		00420
Ensembl ID		ENSG00000255974
Uniprot IDs		P11509
PDB IDs		1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ 4RUI
Enriched GO Terms of Interacting Partners?
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