CTNS and GNMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CTNS	GNMT
Description		cystinosin, lysosomal cystine transporter	glycine N-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Early Endosome Late Endosome Vacuolar Membrane Plasma Membrane Integral Component Of Membrane Melanosome Membrane Melanosome Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton Extracellular Exosome	Cytosol
	Molecular Function	L-cystine Transmembrane Transporter Activity Solute:proton Symporter Activity	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding
	Biological Process	Lens Development In Camera-type Eye Cellular Amino Acid Metabolic Process Glutathione Metabolic Process Ion Transport Brain Development Long-term Memory Grooming Behavior Adult Walking Behavior Visual Learning Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Mitochondrial Membrane Potential Protein Transport L-cystine Transport Melanin Biosynthetic Process ATP Metabolic Process Regulation Of Melanin Biosynthetic Process Cognition Transmembrane Transport Proton Transmembrane Transport Positive Regulation Of TORC1 Signaling	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Miscellaneous transport and binding events	Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation
Drugs		Cystine	Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		1 interacting genes: GNMT	31 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 STT3B TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337
Entrez ID		1497	27232
HPRD ID		05885	05970
Ensembl ID		ENSG00000040531	ENSG00000124713
Uniprot IDs		A0A0S2Z3I9 A0A0S2Z3K3 I3L4A9 O60931	A0A0S2Z5F2 Q14749 V9HW60
PDB IDs			1R74 2AZT
Enriched GO Terms of Interacting Partners?
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