GNMT and HPRT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GNMT	HPRT1
Description		glycine N-methyltransferase	hypoxanthine phosphoribosyltransferase 1
Image
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Identical Protein Binding Guanine Phosphoribosyltransferase Activity
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Adenine Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Hypoxanthine Salvage AMP Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation	Purine salvage
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine	Mercaptopurine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine 3H-pyrazolo[4,3-d]pyrimidin-7-ol 9-Deazaguanine
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		31 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 STT3B TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	12 interacting genes: EEF2KMT EFCAB3 FANCA FXR1 GNMT ISCU NTAQ1 PCNT PRTFDC1 SDCBP SPG21 SREK1IP1
Entrez ID		27232	3251
HPRD ID		05970	02388
Ensembl ID		ENSG00000124713	ENSG00000165704
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	A0A140VJL3 P00492
PDB IDs		1R74 2AZT	1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ
Enriched GO Terms of Interacting Partners?
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