GNMT and KRTAP4-2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		GNMT	KRTAP4-2
Description		glycine N-methyltransferase	keratin associated protein 4-2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol Keratin Filament
	Molecular Function	Protein Binding Folic Acid Binding Glycine Binding Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding	Protein Binding Identical Protein Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Gluconeogenesis Cellular Protein Modification Process Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation	Keratinization
Drugs		Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576 29875488) LDL cholesterol levels ( 32203549) Plasma homocysteine levels (post-methionine load test) ( 24651765)
Interacting Genes		31 interacting genes: ADAMTSL4 ARR3 ARRB1 CCDC153 COX7B CTNS FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 STT3B TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337	124 interacting genes: ADAMTSL4 ALDH3B1 AMOTL2 ANKS1A AQP1 ATG9A AVPI1 AXIN1 BAG4 BYSL CATSPER1 CCER1 CELF5 CHIC2 CHRD CRCT1 CREB5 CRY2 CYP21A2 CYSRT1 DLGAP2 DOCK2 FAM74A4 GLRX3 GNMT GUCD1 HOXA1 HOXB9 HPCAL1 HSD3B7 ITGB4 KPRP KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP26-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP5-2 KRTAP5-3 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 MAFB MEOX2 NBPF19 NECTIN3 NLK NOTCH2NLA NR1D2 NR4A3 NTAQ1 NUFIP2 OTX1 OXER1 PDE9A PGLS PHLDA1 PIN1 PLSCR1 PLSCR4 POM121L8P POU4F2 PRKAB2 PRKAG1 PSMA6 RASSF5 RGS20 SDC3 SHFL SLC23A1 SLC25A10 SMCP SPATA24 SPATA3 SPRY1 TCEANC TINAGL1 TRIM42 TXNDC5 TYRO3 VASN VGLL3 YY1 ZBTB24 ZNF124 ZNF20 ZNF417 ZNF559 ZNF581 ZNF688
Entrez ID		27232	85291
HPRD ID		05970	13944
Ensembl ID		ENSG00000124713	ENSG00000244537
Uniprot IDs		A0A0S2Z5F2 Q14749 V9HW60	Q9BYR5
PDB IDs		1R74 2AZT
Enriched GO Terms of Interacting Partners?
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