COMP and AQP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		COMP	AQP1
Description		cartilage oligomeric matrix protein	aquaporin 1 (Colton blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Symbiont-containing Vacuole Membrane Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding	Intracellular CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Transmembrane Transporter Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding
	Biological Process	Skeletal System Development Chondrocyte Development Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Protein Secretion Animal Organ Morphogenesis Multicellular Organism Aging Animal Organ Senescence Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Artery Morphogenesis Musculoskeletal Movement Limb Development Platelet Aggregation Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation	Renal Water Homeostasis Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Cellular Water Homeostasis Carbon Dioxide Transport Ammonium Transport Glycerol Transport Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Odontogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Defense Response To Gram-negative Bacterium Multicellular Organismal Water Homeostasis Cellular Response To Hydrogen Peroxide Cellular Response To Inorganic Substance Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport
Pathways		Integrin cell surface interactions ECM proteoglycans	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs		Calcium	Acetazolamide B-nonylglucoside Mersalyl
Diseases
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)	Fractures ( 30598549) Heel bone mineral density ( 30598549 28869591) hemolysis of donated blood (osmotic) ( 34014839) Huntington's disease progression ( 28642124) Kidney stones ( 31729369) Nephrolithiasis ( 22396660) Systolic blood pressure ( 30224653) Total body bone mineral density ( 29304378) Triglyceride levels ( 34074324) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB	134 interacting genes: ADAMTSL4 AMOT AQP6 BCL2L13 BEGAIN BHLHB9 BLZF1 BMF CCDC136 CCDC57 CCDC85B CCNDBP1 CD79A CDR2 CEP44 CLDN5 COMP CPLX4 CREB3 CRTAC1 CSRNP1 CYSRT1 EFEMP2 EPHB2 ESM1 EVI2B FAM161A FAM209A FNDC9 FOS FSD2 GET1 GJB5 GLI1 GOLGA2 GPR37L1 GPX8 IFT20 IGFBP6 IHO1 IKZF2 IKZF3 IL21R KCNK5 KCTD17 KCTD9 KHDRBS3 KIAA1958 KLHL26 KRT31 KRT33B KRT37 KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-4 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE1A LDLRAD1 LDOC1 LIME1 LMNA LPXN LRRC59 MDFI MGST3 MID2 MIF4GD MKRN3 MRM1 MTUS2 MUC1 MYF5 NBPF19 NBPF22P NBPF6 NOTCH2NLA NUTM1 PGPEP1 PICK1 PLA2G10 PLSCR2 PPARA PRDM14 PRDM6 RBAK REL RGS17 RGS20 RIMBP3 RNF122 SAR1A SIAH1 SIVA1 SLC15A2 SLC39A2 SPDYA SPRED1 SPRED2 SPRY2 SPRY3 SPRYD7 SSMEM1 TCF4 TMEM237 TMEM38B TMEM45B TMEM80 TMPRSS2 TNK2 TNS2 TRAF1 TRAF2 TRIM23 TRIM37 TRIM41 TRIM42 TRIM7 TRIP6 TSC1 ZBTB39 ZIM2 ZNF16 ZNF398 ZNF792
Entrez ID		1311	358
HPRD ID		02632	00140
Ensembl ID		ENSG00000105664	ENSG00000240583
Uniprot IDs		P49747	A0A024RA31 P29972
PDB IDs		3FBY	1FQY 1H6I 1IH5 4CSK 6POJ
Enriched GO Terms of Interacting Partners?
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