COMP and COL2A1

Number of citations of the paper that reports this interaction (PubMedID 9685393)
90

Data Source:
HPRD (in vitro)

		COMP	COL2A1
Description		cartilage oligomeric matrix protein	collagen type II alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Collagen Trimer Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Chondrocyte Development Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Protein Secretion Animal Organ Morphogenesis Multicellular Organism Aging Animal Organ Senescence Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Artery Morphogenesis Musculoskeletal Movement Limb Development Platelet Aggregation Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Organization Collagen Fibril Organization Notochord Development Inner Ear Morphogenesis Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Integrin cell surface interactions ECM proteoglycans	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs		Calcium	Collagenase clostridium histolyticum
Diseases
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)	Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314) Triglyceride levels ( 32902719)
Interacting Genes		10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB	33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		1311	1280
HPRD ID		02632	00361
Ensembl ID		ENSG00000105664	ENSG00000139219
Uniprot IDs		P49747	P02458
PDB IDs		3FBY	1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6NIX
Enriched GO Terms of Interacting Partners?
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