COMP

Description		cartilage oligomeric matrix protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Heparin Binding BMP Binding Proteoglycan Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Skeletal System Development Chondrocyte Development Growth Plate Cartilage Development Apoptotic Process Response To Unfolded Protein Protein Secretion Animal Organ Morphogenesis Multicellular Organism Aging Animal Organ Senescence Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Protein Processing Collagen Fibril Organization Bone Mineralization Regulation Of Bone Mineralization BMP Signaling Pathway Multicellular Organism Growth Chondrocyte Proliferation Tendon Development Negative Regulation Of Apoptotic Process Skin Development Artery Morphogenesis Musculoskeletal Movement Limb Development Platelet Aggregation Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Hemostasis Positive Regulation Of Chondrocyte Proliferation
Pathways		Integrin cell surface interactions ECM proteoglycans
Drugs		Calcium
Diseases
GWAS		Osteoarthritis (with total hip replacement) ( 28319091) Osteoarthritis biomarkers ( 25057126) QT interval ( 29213071)
Interacting Genes		10 interacting genes: AQP1 ATOX1 COL2A1 COL9A1 CYSRT1 FN1 MEOX2 NUFIP2 OTX1 SGTB
Entrez ID		1311
HPRD ID		02632
Ensembl ID		ENSG00000105664
Uniprot IDs		P49747
PDB IDs		3FBY
Enriched GO Terms of Interacting Partners?
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