PRRT2 and KAT8

		PRRT2	KAT8
Description		proline rich transmembrane protein 2	lysine acetyltransferase 8
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Vesicle Presynaptic Membrane Dendritic Spine Axon Terminus Presynapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Matrix MLL1 Complex MSL Complex
	Molecular Function	Protein Binding Syntaxin-1 Binding SH3 Domain Binding	Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of SNARE Complex Assembly Neuromuscular Process Controlling Posture Calcium-dependent Activation Of Synaptic Vesicle Fusion Negative Regulation Of Short-term Synaptic Potentiation	Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			HATs acetylate histones
Drugs
Diseases
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		13 interacting genes: AQP6 CFAP119 F2RL1 GPRC5D KAT8 MFSD14B ORAI3 SLC10A6 SMIM5 SNAP25 TLCD4 TMEM219 ZNF689	22 interacting genes: ATM BAZ1B BAZ2A CFAP119 CLEC4A FOXP3 H4C1 KMT2A LIMS1 NFATC2IP ORAI3 PAF1 PLAU PRRT2 RABEP2 RNF2 SLC7A5P1 SRY SSTR5 TP53 TP53BP1 ZNF764
Entrez ID		112476	84148
HPRD ID		13995	11381
Ensembl ID		ENSG00000167371	ENSG00000103510
Uniprot IDs		Q7Z6L0	Q9H7Z6
PDB IDs			2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR
Enriched GO Terms of Interacting Partners?
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