KAT8 and KMT2A

Number of citations of the paper that reports this interaction (PubMedID 15960975)
289

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		KAT8	KMT2A
Description		lysine acetyltransferase 8	lysine methyltransferase 2A
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Matrix MLL1 Complex MSL Complex	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1 Complex
	Molecular Function	Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)	Minor Groove Of Adenine-thymine-rich DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Unmethylated CpG Binding Lysine-acetylated Histone Binding Protein-cysteine Methyltransferase Activity
	Biological Process	Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Apoptotic Process Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Histone H3-K4 Dimethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Protein-containing Complex Assembly Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Negative Regulation Of DNA Methylation Regulation Of Histone H3-K9 Acetylation
Pathways		HATs acetylate histones	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		22 interacting genes: ATM BAZ1B BAZ2A CFAP119 CLEC4A FOXP3 H4C1 KMT2A LIMS1 NFATC2IP ORAI3 PAF1 PLAU PRRT2 RABEP2 RNF2 SLC7A5P1 SRY SSTR5 TP53 TP53BP1 ZNF764	43 interacting genes: ASH2L AVP BMI1 CBX4 CKMT1A CREBBP CTNNB1 DCTN1 EXOSC5 FASLG H3-3A H3-4 H3C14 HCFC1 HCFC2 IL10RA INPPL1 INS KAT8 LAYN MCTS1 MEN1 MTM1 OXT PAF1 PAFAH1B2 PLAAT4 PLPP2 PLXNB1 PPIE PPP1R15A RBBP5 RDX RNF2 SBF1 SET SVIL TAF9 TASP1 TGFB2 TOP1 VWA5A WDR5
Entrez ID		84148	4297
HPRD ID		11381	01162
Ensembl ID		ENSG00000103510	ENSG00000118058
Uniprot IDs		Q9H7Z6	Q03164
PDB IDs		2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR	2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ 6PWV 6PWW 6U9K 6U9M 6U9N 6U9R
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?