SUPT16H and NEK9

Number of citations of the paper that reports this interaction (PubMedID 14660563)
24

Data Source:
HPRD (in vivo)

		SUPT16H	NEK9
Description		SPT16 homolog, facilitates chromatin remodeling subunit	NIMA related kinase 9
Image
GO Annotations	Cellular Component	Nucleoplasm FACT Complex	Nucleus Centrosome Cytosol
	Molecular Function	RNA Binding Protein Binding Nucleosome Binding	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	DNA Replication DNA Repair Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter DNA Replication-independent Nucleosome Organization	Protein Phosphorylation Cell Cycle Cell Division
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		12 interacting genes: CCT6A GTF2E2 H2AC13 H3-3A MCM3 MCM4 NEK9 NGDN PARP1 SREK1 SRPK2 SUMO2	21 interacting genes: BICD2 CSN2 GABARAP GZMB IFT43 JDP2 LIN52 MALL MAP1LC3B MBP NEK6 NEK7 NEK8 PALS1 RAN RARG RPS6KL1 SSRP1 SUPT16H TTN WDR33
Entrez ID		11198	91754
HPRD ID		16088	11386
Ensembl ID		ENSG00000092201	ENSG00000119638
Uniprot IDs		Q9Y5B9	A0A7I2V454 A0A7I2V5R1 Q6PKF2 Q8TD19
PDB IDs		4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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