EGLN3 and IK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EGLN3	IK
Description		egl-9 family hypoxia inducible factor 3	IK cytokine
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Mitotic Spindle Pole
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Population Proliferation Regulation Of Neuron Apoptotic Process Cellular Response To Hypoxia	Mitotic Cell Cycle MRNA Splicing, Via Spliceosome Mitotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Ascorbic acid Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Red blood cell count ( 32888494)	Monocyte count ( 32888494) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		39 interacting genes: ABI2 ADRB2 ATF4 CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	27 interacting genes: APP CEP70 CHD3 CTNNBL1 DDX6 EGLN3 FANCC FRA10AC1 FXR1 GRB2 KAT5 KDM1A MBD3 MFAP1 NUP62 OGT PFN2 QARS1 RACK1 RBM10 SUPT5H THOC1 TOE1 TRIM55 TRIM63 TTC14 ZCCHC10
Entrez ID		112399	3550
HPRD ID		06972	02771
Ensembl ID		ENSG00000129521	ENSG00000113141
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	Q13123 Q95HA6 Q9UK43
PDB IDs			5O9Z 6Q8I
Enriched GO Terms of Interacting Partners?
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