EDAR and UPK1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EDAR	UPK1B
Description		ectodysplasin A receptor	uroplakin 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Integral Component Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity	Structural Molecule Activity Protein Binding
	Biological Process	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of NIK/NF-kappaB Signaling	Response To Bacterium Epithelial Cell Differentiation
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Blood protein levels ( 30072576 29875488 28240269) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819) Urinary albumin-to-creatinine ratio ( 32600054)	Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042)
Interacting Genes		8 interacting genes: EDA EDARADD MAP3K14 SGTA TRAF1 TRAF2 TRAF3 UPK1B	55 interacting genes: BCL2L13 BEST2 BNIP2 CD53 CD69 CD80 CERS4 CLDN7 DAGLA EDAR FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 IQCB1 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A2 SLC16A2 SLC35C2 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM262 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1
Entrez ID		10913	7348
HPRD ID		04974	03853
Ensembl ID		ENSG00000135960	ENSG00000114638
Uniprot IDs		Q9UNE0	O75841
PDB IDs
Enriched GO Terms of Interacting Partners?
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