EDAR and EDA

Number of citations of the paper that reports this interaction (PubMedID 11309369)
26

Data Source:
HPRD (in vitro, in vivo)

		EDAR	EDA
Description		ectodysplasin A receptor	ectodysplasin A
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity Receptor Ligand Activity
	Biological Process	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of NIK/NF-kappaB Signaling	Immune Response Cell-matrix Adhesion Signal Transduction Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Animal Organ Development Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Blood protein levels ( 30072576 29875488 28240269) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819) Urinary albumin-to-creatinine ratio ( 32600054)	Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		8 interacting genes: EDA EDARADD MAP3K14 SGTA TRAF1 TRAF2 TRAF3 UPK1B	24 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 NIPAL3 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60
Entrez ID		10913	1896
HPRD ID		04974	02347
Ensembl ID		ENSG00000135960	ENSG00000158813
Uniprot IDs		Q9UNE0	A0A0U5J797 Q92838
PDB IDs			1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?