UPK1B and CERS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UPK1B	CERS4
Description		uroplakin 1B	ceramide synthase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Integral Component Of Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Response To Bacterium Epithelial Cell Differentiation	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042)	Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		55 interacting genes: BCL2L13 BEST2 BNIP2 CD53 CD69 CD80 CERS4 CLDN7 DAGLA EDAR FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 IQCB1 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A2 SLC16A2 SLC35C2 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM262 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1	47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		7348	79603
HPRD ID		03853	13962
Ensembl ID		ENSG00000114638	ENSG00000090661
Uniprot IDs		O75841	Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?
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