NCKAP1 and CYFIP2

Number of citations of the paper that reports this interaction (PubMedID 15048123)
152

Data Source:
HPRD (in vivo, in vitro)

		NCKAP1	CYFIP2
Description		NCK associated protein 1	cytoplasmic FMR1 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Integral Component Of Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Extracellular Exosome	Nucleus Cytoplasm Cytosol Membrane SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding
	Biological Process	Cell Morphogenesis Apoptotic Process Central Nervous System Development Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Neuron Projection Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Morphogenesis Apoptotic Process Regulation Of Actin Filament Polymerization Positive Regulation Of Proteolysis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Dendrite Extension Cell-cell Adhesion
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Neurological blood protein biomarker levels ( 31320639)	Alanine aminotransferase levels ( 33547301) Asthma ( 31959851 34103634 32296059) Daytime sleep phenotypes ( 27126917) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)
Interacting Genes		14 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 WASF1 WASF2 YWHAG	23 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP F2RL1 FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 OXTR PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A
Entrez ID		10787	26999
HPRD ID		05353	07556
Ensembl ID		ENSG00000061676	ENSG00000055163
Uniprot IDs		Q9Y2A7	B7Z8N7 E7EVJ5 Q96F07
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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