CYFIP2 and BRK1

Number of citations of the paper that reports this interaction (PubMedID 8605018)
25

Data Source:
HPRD (in vitro, in vivo)

		CYFIP2	BRK1
Description		cytoplasmic FMR1 interacting protein 2	BRICK1 subunit of SCAR/WAVE actin nucleating complex
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome
	Molecular Function	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Cell Morphogenesis Apoptotic Process Regulation Of Actin Filament Polymerization Positive Regulation Of Proteolysis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Dendrite Extension Cell-cell Adhesion	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma ( 31959851 34103634 32296059) Daytime sleep phenotypes ( 27126917) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Arterial stiffness index ( 31235810)
Interacting Genes		23 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP F2RL1 FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 OXTR PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A	10 interacting genes: BRAP CYFIP2 HSBP1 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1
Entrez ID		26999	55845
HPRD ID		07556	12818
Ensembl ID		ENSG00000055163	ENSG00000254999
Uniprot IDs		B7Z8N7 E7EVJ5 Q96F07	Q8WUW1
PDB IDs			3P8C 4N78
Enriched GO Terms of Interacting Partners?
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