ERN2 and IL4R

		ERN2	IL4R
Description		endoplasmic reticulum to nucleus signaling 2	interleukin 4 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Endoplasmic Reticulum Quality Control Compartment IRE1-TRAF2-ASK1 Complex	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Magnesium Ion Binding Endonuclease Activity Endoribonuclease Activity Protein Serine/threonine Kinase Activity ATP Binding Unfolded Protein Binding Protein Serine Kinase Activity	Interleukin-4 Receptor Activity Protein Binding
	Biological Process	MRNA Processing Protein Phosphorylation RRNA Catabolic Process Apoptotic Chromosome Condensation Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant
Pathways			Interleukin-4 and Interleukin-13 signaling
Drugs			AER001 Dupilumab
Diseases
GWAS			Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		1 interacting genes: IL4R	28 interacting genes: ARIH2 CD40 DOK2 ERN2 FES HDGFL3 HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 NPIPB5 PRKCZ PTPN11 PTPN6 RACK1 RBBP6 SHC1 SLC20A1 SOCS5 STAT6
Entrez ID		10595	3566
HPRD ID		04944	00990
Ensembl ID		ENSG00000134398	ENSG00000077238
Uniprot IDs		A5YM46 A5YM65 E7ETG2 Q76MJ5	B2RBY1 P24394
PDB IDs			1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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