TMEM147 and PDCD1LG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM147	PDCD1LG2
Description		transmembrane protein 147	programmed cell death 1 ligand 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Protein-containing Complex	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Endomembrane System Integral Component Of Membrane
	Molecular Function	Protein Binding Ribosome Binding	Molecular_function Protein Binding
	Biological Process		Adaptive Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Cellular Response To Lipopolysaccharide
Pathways			PD-1 signaling
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)	Blood protein levels ( 30072576 29875488 28240269) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		55 interacting genes: ABHD16A ABI3 CD200 CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 DPM3 EBP EFNA4 ENPP4 F11R FFAR2 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PACC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC22A1 SLC22A2 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12	21 interacting genes: ATP6V0C ERMP1 EXOSC8 GALNT15 GPR37L1 KTN1 LRP10 MFSD6 PDCD1 RUSF1 SLC35C2 SLC38A1 SLC38A7 SLC41A2 SLC7A1 SMIM3 TAS2R10 TMEM147 TMEM218 TMEM239 TMEM97
Entrez ID		10430	80380
HPRD ID		17633	16147
Ensembl ID		ENSG00000105677	ENSG00000197646
Uniprot IDs		Q9BVK8	Q9BQ51
PDB IDs		6W6L	6UMT
Enriched GO Terms of Interacting Partners?
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