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CALCOCO2 and FMR1
Number of citations of the paper that reports this interaction (PubMedID
21903422
)
143
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
CALCOCO2
FMR1
Description
calcium binding and coiled-coil domain 2
FMRP translational regulator 1
Image
GO Annotations
Cellular Component
Autophagosome Membrane
Nucleus
Cytoplasm
Autophagosome
Cytosol
Cytoskeleton
Membrane
PML Body
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Chromosome, Centromeric Region
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Polysome
MRNA Cap Binding Complex
Chromocenter
Cytoplasmic Stress Granule
Postsynaptic Density
Cajal Body
Membrane
Extrinsic Component Of Plasma Membrane
Axon
Dendrite
Growth Cone
Filopodium Tip
Cytoplasmic Ribonucleoprotein Granule
Presynaptic Membrane
Cell Projection
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Perikaryon
Axon Terminus
Dendritic Spine Neck
Synapse
Postsynaptic Membrane
Perinuclear Region Of Cytoplasm
Neuronal Ribonucleoprotein Granule
Glial Cell Projection
Presynapse
Postsynapse
Dendritic Filopodium
Messenger Ribonucleoprotein Complex
Growth Cone Filopodium
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
G-quadruplex RNA Binding
Chromatin Binding
RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Protein Binding
Microtubule Binding
Poly(U) RNA Binding
Translation Repressor Activity
Translation Initiation Factor Binding
RNA Strand Annealing Activity
Poly(G) Binding
Methylated Histone Binding
SiRNA Binding
MiRNA Binding
RNA Stem-loop Binding
Identical Protein Binding
Protein Homodimerization Activity
Ribosome Binding
Transmembrane Transporter Binding
Translation Regulator Activity
Protein Heterodimerization Activity
MRNA 5'-UTR Binding
Dynein Complex Binding
Sequence-specific MRNA Binding
Biological Process
Viral Process
Response To Interferon-gamma
Xenophagy
Positive Regulation Of Autophagosome Maturation
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Receptor Internalization
MRNA Processing
Cellular Response To DNA Damage Stimulus
Glutamate Receptor Signaling Pathway
Nervous System Development
RNA Splicing
Negative Regulation Of Translation
Gene Silencing By RNA
Positive Regulation Of Histone Phosphorylation
Cellular Response To UV
Regulation Of MRNA Stability
Modulation By Host Of Viral RNA Genome Replication
Positive Regulation Of Translation
Negative Regulation Of Translational Initiation
Regulation Of Neurotransmitter Secretion
MRNA Transport
Regulation Of Filopodium Assembly
Positive Regulation Of Filopodium Assembly
Regulation Of Gene Silencing By MiRNA
Regulation Of Dendritic Spine Development
Positive Regulation Of Dendritic Spine Development
Cellular Response To Hydroxyurea
Cellular Response To Virus
Regulation Of Neuronal Action Potential
Negative Regulation Of Long-term Synaptic Depression
Positive Regulation Of Intracellular Transport Of Viral Material
Negative Regulation Of Voltage-gated Calcium Channel Activity
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of MRNA Catabolic Process
Positive Regulation Of MRNA Binding
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Cytoplasmic Translation
Positive Regulation Of Response To DNA Damage Stimulus
Pathways
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Chronotype (
30696823
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Serum alkaline phosphatase levels (
33547301
)
Type 2 diabetes (
29358691
29632382
)
Type 2 diabetes (adjusted for BMI) (
29632382
)
Antineutrophil cytoplasmic antibody-associated vasculitis (
22808956
)
Fragile X syndrome (
30531935
)
Interacting Genes
183 interacting genes:
ABLIM1
ADSL
AKAP17A
AMMECR1
AP5B1
APEX2
ARHGEF39
ARHGEF5
ARNT2
ATG5
AXIN1
BAHD1
BCL6B
BEX2
CBX8
CCDC120
CCDC185
CCDC33
CCNH
CDC7
CELA2B
CEP57L1
CHCHD3
CNNM3
CPNE7
CWF19L2
DAXX
DAZAP2
DBNDD2
DCTN4
DCX
DDIT4L
DDX6
DOCK2
DUSP12
DUSP26
EEF1E1
EFHC1
ELOA2
ENKD1
EXOSC5
FAM107A
FAM161A
FAM168A
FAM189A2
FAM214B
FAM90A1
FARS2
FASTK
FBF1
FBXL18
FKBPL
FMR1
FNDC11
FOXD4L3
FXR2
GABARAPL1
GABARAPL2
GATAD2B
GCA
GEMIN4
GIT2
GLYCTK
HDAC4
HDAC7
HLX
HNRNPLL
HOXB5
HOXB9
IKBKG
IL16
IQUB
KANSL1
KAT7
KLHL35
KLHL42
LENG1
LGALS8
LGALS9
LIMS2
LITAF
LMF2
LMO2
LMO4
LNX1
LONRF1
LSM4
MAGOHB
MAP1LC3C
MCM10
METTL17
MID2
MOS
MTPAP
MVP
MXI1
MYH6
MYO6
NAA10
NDN
NFU1
ORC5
PCGF1
PEF1
PEG10
PFDN5
PHF1
PIAS4
PLEKHN1
POLI
POLR2A
PPP1R18
PRKAA2
PRKAB2
PRPF18
PRPF31
PSMA1
PSME4
PTBP1
PTBP2
QARS1
RAB35
RABL6
RBM15
RHPN1
RIN1
RNF11
RPA2
RPL9
RPS27A
RTN4IP1
RTP5
RXRB
SCAND1
SCNM1
SDCBP
SETD5
SHC1
SLC15A3
SMARCD1
SMCP
SNRPB
SPATA24
SRI
STAMBPL1
STK16
TACO1
TBC1D22B
TBK1
TBKBP1
TBRG4
TCL1A
TEKT3
TENT2
TLE5
TP53RK
TRAF2
TRAF4
TRAF6
TSC1
TSGA10IP
TTC23L
UBAC2
USP2
VARS1
VPS72
ZBTB4
ZC2HC1C
ZNF101
ZNF205
ZNF337
ZNF408
ZNF414
ZNF426
ZNF451
ZNF564
ZNF581
ZNF638
ZNF648
ZNF688
ZNF696
ZNF774
ZNF80
48 interacting genes:
AKAP9
ALDOC
ATG5
BEX4
CALCOCO2
CAMK2B
CASK
CCAR2
CWC25
CYFIP1
CYFIP2
DCTPP1
DGKD
EFHC1
FSD2
FXR1
FXR2
GRIP2
HOMER3
INCA1
LIMS1
MAGI3
MEOX1
MVP
NCL
NECAB2
NUFIP1
NUFIP2
PICK1
POLR1C
PPP1R12C
PSME3
RANBP9
RBM14
SF3B2
SFPQ
SHARPIN
SPAG5
SRC
STAU1
SUOX
TACC2
UBE2I
WBP2NL
YBX1
ZBTB42
ZFPM2
ZMYND8
Entrez ID
10241
2332
HPRD ID
06846
02398
Ensembl ID
ENSG00000136436
ENSG00000102081
Uniprot IDs
Q13137
Q06787
PDB IDs
2MXP
3VVV
3VVW
4GXL
4HAN
4XKL
5AAQ
5Z7A
5Z7L
2BKD
2FMR
2LA5
2QND
4OVA
4QVZ
4QW2
5DE5
5DE8
5DEA
5UWJ
5UWO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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