CALCOCO2 and DUSP26

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CALCOCO2	DUSP26
Description		calcium binding and coiled-coil domain 2	dual specificity phosphatase 26
Image
GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Extracellular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity Metal Ion Binding	P53 Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity L-phosphoserine Phosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Viral Process Response To Interferon-gamma Xenophagy Positive Regulation Of Autophagosome Maturation	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAPK Cascade Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Cell Adhesion Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Peptidyl-serine Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Body mass index ( 28892062 25673413) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Morning person ( 30696823) Reading disability ( 32108986) Self-reported risk-taking behaviour ( 30271922)
Interacting Genes		183 interacting genes: ABLIM1 ADSL AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 AXIN1 BAHD1 BCL6B BEX2 CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM214B FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FMR1 FNDC11 FOXD4L3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPLL HOXB5 HOXB9 IKBKG IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LGALS9 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 PLEKHN1 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 QARS1 RAB35 RABL6 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBK1 TBKBP1 TBRG4 TCL1A TEKT3 TENT2 TLE5 TP53RK TRAF2 TRAF4 TRAF6 TSC1 TSGA10IP TTC23L UBAC2 USP2 VARS1 VPS72 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80	11 interacting genes: CALCOCO2 CARD10 EPHA2 EPHA7 GOLGA6L9 GRIPAP1 HSF4 IGF1R KRT27 PTK7 RET
Entrez ID		10241	78986
HPRD ID		06846	14421
Ensembl ID		ENSG00000136436	ENSG00000133878
Uniprot IDs		Q13137	Q9BV47
PDB IDs		2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L	2E0T 4B04 4HRF 5GTJ
Enriched GO Terms of Interacting Partners?
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