FMR1 and TACC2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		FMR1	TACC2
Description		FMRP translational regulator 1	transforming acidic coiled-coil containing protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Extrinsic Component Of Plasma Membrane Axon Dendrite Growth Cone Filopodium Tip Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Dendritic Spine Neck Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Messenger Ribonucleoprotein Complex Growth Cone Filopodium Ribonucleoprotein Complex	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane
	Molecular Function	G-quadruplex RNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding Methylated Histone Binding SiRNA Binding MiRNA Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Sequence-specific MRNA Binding	Nuclear Receptor Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization MRNA Processing Cellular Response To DNA Damage Stimulus Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of Histone Phosphorylation Cellular Response To UV Regulation Of MRNA Stability Modulation By Host Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion MRNA Transport Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Gene Silencing By MiRNA Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Cellular Response To Hydroxyurea Cellular Response To Virus Regulation Of Neuronal Action Potential Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Binding Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Cytoplasmic Translation Positive Regulation Of Response To DNA Damage Stimulus	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Cell Population Proliferation Cerebral Cortex Development
Pathways
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)	Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Hepcidin/ferritin ratio ( 27846281) Metabolite risk score for predicting weight gain ( 31560688) Myopia (pathological) ( 23049088) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Obesity-related traits ( 23251661) Opioid dependence ( 31250797) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Total body bone mineral density ( 29304378)
Interacting Genes		48 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 SRC STAU1 SUOX TACC2 UBE2I WBP2NL YBX1 ZBTB42 ZFPM2 ZMYND8	18 interacting genes: AURKC BORCS6 CLK2 CLVS2 CREBBP EP300 FMR1 FXR1 GRAMD4 HMG20B KAT2A KAT2B PPP1CC RXRB SMARCA2 SMARCB1 TGM1 YEATS4
Entrez ID		2332	10579
HPRD ID		02398	05600
Ensembl ID		ENSG00000102081	ENSG00000138162
Uniprot IDs		Q06787	B2RWP4 B7ZMJ9 D6RAA5 O95359 Q4VXL4 Q4VXL8
PDB IDs		2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO
Enriched GO Terms of Interacting Partners?
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