XRCC1 and APLF

Number of citations of the paper that reports this interaction (PubMedID 17353262)
74

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		XRCC1	APLF
Description		X-ray repair cross complementing 1	aprataxin and PNKP like factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Single Strand Break Repair Response To Hypoxia Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Xenobiotic Stimulus Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Single Strand Break Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)	Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		20 interacting genes: APEX1 APLF APTX BRCA1 BTRC CHD1L CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I	7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		7515	200558
HPRD ID		01909	09848
Ensembl ID		ENSG00000073050	ENSG00000169621
Uniprot IDs		B2RCY5 P18887 Q59HH7	Q8IW19
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2	2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ
Enriched GO Terms of Interacting Partners?
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