XRCC1 and LIG3

Number of citations of the paper that reports this interaction (PubMedID 11163244)
177

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		XRCC1	LIG3
Description		X-ray repair cross complementing 1	DNA ligase 3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex	Nucleoplasm Cytoplasm Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Single Strand Break Repair Response To Hypoxia Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Xenobiotic Stimulus Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange	Double-strand Break Repair Via Homologous Recombination DNA Ligation Lagging Strand Elongation Base-excision Repair, Gap-filling Base-excision Repair, DNA Ligation Double-strand Break Repair Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			Bleomycin
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits (multivariate) ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 19305408 29874175) TPE interval (resting) ( 32386560)
Interacting Genes		20 interacting genes: APEX1 APLF APTX BRCA1 BTRC CHD1L CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I	8 interacting genes: APP JTB NEIL1 PARP1 TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		7515	3980
HPRD ID		01909	02966
Ensembl ID		ENSG00000073050	ENSG00000005156
Uniprot IDs		B2RCY5 P18887 Q59HH7	P49916
PDB IDs		1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG 6WH1
Enriched GO Terms of Interacting Partners?
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