SDC3 and CTTN

Data Source:
HPRD (in vitro)

		SDC3	CTTN
Description		syndecan 3	cortactin
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Lysosomal Lumen Microspike Collagen-containing Extracellular Matrix	Ruffle Podosome Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Site Of Polarized Growth Cortical Cytoskeleton Cortical Actin Cytoskeleton Dendritic Spine Intracellular Membrane-bounded Organelle Mitotic Spindle Midzone
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Profilin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cell Migration Leukocyte Migration	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Membrane Organization Dendritic Spine Maintenance Lamellipodium Organization Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	RHO GTPases activate PAKs Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Loneliness ( 27629369)
Interacting Genes		32 interacting genes: AGR2 CASK CMTM7 COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KCNJ2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 LCE3D MDK PLN PTN SLC35A1 SMIM1 TMEM14C TMEM218 TUBA1A TUBB TUBB2A	42 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 RPL9 SDC3 SH3BP2 SHANK2 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 WASL WIPF1
Entrez ID		9672	2017
HPRD ID		01719	01268
Ensembl ID		ENSG00000162512	ENSG00000085733
Uniprot IDs		O75056	A0A024R5M3 Q14247 Q53HG7
PDB IDs			1X69 2D1X
Enriched GO Terms of Interacting Partners?
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