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SDC3 and AGR2
Data Source:
BioGRID
(two hybrid)
SDC3
AGR2
Description
syndecan 3
anterior gradient 2, protein disulphide isomerase family member
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Lumen
Plasma Membrane
Cell Surface
Membrane
Integral Component Of Membrane
Lysosomal Lumen
Microspike
Collagen-containing Extracellular Matrix
Extracellular Space
Endoplasmic Reticulum
Molecular Function
Protein Binding
Identical Protein Binding
Dystroglycan Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
Identical Protein Binding
Biological Process
Retinoid Metabolic Process
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Cell Migration
Leukocyte Migration
Positive Regulation Of Gene Expression
Positive Regulation Of Cell-substrate Adhesion
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Digestive Tract Morphogenesis
Positive Regulation Of Developmental Growth
Negative Regulation Of Cell Death
Mucus Secretion
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport
Drugs
Diseases
GWAS
Loneliness (
27629369
)
Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) (
23648065
)
Iron status biomarkers (ferritin levels) (
28334935
)
Residual cognition (
28441426
)
Type 2 diabetes (dietary heme iron intake interaction) (
23386860
)
Interacting Genes
32 interacting genes:
AGR2
CASK
CMTM7
COL5A1
CSK
CTTN
CUX1
EPHB4
FGF2
FYN
ITGB4
KCNJ2
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP2-3
KRTAP2-4
KRTAP4-2
KRTAP5-7
KRTAP5-9
KRTAP9-2
LCE3D
MDK
PLN
PTN
SLC35A1
SMIM1
TMEM14C
TMEM218
TUBA1A
TUBB
TUBB2A
87 interacting genes:
ANKRD11
APOBEC3B
APP
ASPH
BORCS8
BORCS8-MEF2B
BRD7
C3
CAMLG
CATSPER1
CCDC90B
CD34
CD68
CDKN2AIPNL
CETN3
CKAP2
CLIC3
CNNM3
CPNE6
CRCP
CREB1
CRMP1
CRYGA
CYB5R2
DAG1
DCAF11
EIF3F
FABP2
FAM110A
FAM117B
GET3
GPSM2
GRB2
GUCA1A
HCK
HMG20A
HSD3B7
IL36RN
IMPDH2
KLHL38
KRT31
LSM1
LYPD3
MBD3
MBLAC1
MED31
MLH1
NDUFB2
NRF1
NRIP1
NSD1
NTAQ1
NUP54
NUP58
NUP62CL
OSTF1
PHC3
POGZ
POLR2L
POM121
PSMA1
PSMB1
PSORS1C2
PTTG2
RBFOX1
RBP5
RIIAD1
RTL4
RUVBL2
SDC3
SGTA
SGTB
SH2D1B
STK16
TCEA2
TFAP2D
THOC1
TLE5
TMEM123
TRAF2
TSTD2
UBE2I
UBQLN1
UBQLN2
UBQLN4
USP20
VEZF1
Entrez ID
9672
10551
HPRD ID
01719
05896
Ensembl ID
ENSG00000162512
ENSG00000106541
Uniprot IDs
O75056
O95994
Q4JM46
PDB IDs
2LNS
2LNT
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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