SDC3 and SLC35A1

Data Source:
BioGRID (two hybrid)

		SDC3	SLC35A1
Description		syndecan 3	solute carrier family 35 member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Lysosomal Lumen Microspike Collagen-containing Extracellular Matrix	Golgi Membrane Golgi Apparatus Integral Component Of Plasma Membrane Integral Component Of Membrane Integral Component Of Golgi Membrane
	Molecular Function	Protein Binding Identical Protein Binding	CMP-N-acetylneuraminate Transmembrane Transporter Activity UDP-galactose Transmembrane Transporter Activity Protein Binding Antiporter Activity
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cell Migration Leukocyte Migration	Carbohydrate Metabolic Process Cellular Protein Modification Process Carbohydrate Transport CMP-N-acetylneuraminate Transmembrane Transport UDP-galactose Transmembrane Transport
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	Sialic acid metabolism Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Transport of nucleotide sugars
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Loneliness ( 27629369)	Bone mineral density (hip) ( 30172743) Obesity-related traits ( 23251661)
Interacting Genes		32 interacting genes: AGR2 CASK CMTM7 COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN ITGB4 KCNJ2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 LCE3D MDK PLN PTN SLC35A1 SMIM1 TMEM14C TMEM218 TUBA1A TUBB TUBB2A	36 interacting genes: AQP6 ARL13B ASGR2 ASZ1 BCL2L13 CD53 CERS4 CPLX4 EBAG9 ERGIC3 F11R F2RL1 FAM209A FNDC9 FXYD3 GPX8 KIR3DL3 LHFPL5 LMNA MCFD2 MGST3 MRPS18B PIK3IP1 PLPP4 PSCA RELL2 SAR1A SDC3 SLC1A1 SLC34A2 SSMEM1 SYT2 TCTA TMEM139 TMPRSS2 TMX2
Entrez ID		9672	10559
HPRD ID		01719	09290
Ensembl ID		ENSG00000162512	ENSG00000164414
Uniprot IDs		O75056	P78382
PDB IDs
Enriched GO Terms of Interacting Partners?
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