VHL and UBE2D1

Data Source:
BioGRID (pull down)

		VHL	UBE2D1
Description		von Hippel-Lindau tumor suppressor	ubiquitin conjugating enzyme E2 D1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Ligase-substrate Adaptor Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Peroxisome Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Polyubiquitination
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex TICAM1, RIP1-mediated IKK complex recruitment APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Signaling by BMP Downstream TCR signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Ovarian tumor domain proteases CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Renal cell carcinoma von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS			Brain imaging ( 20100581) Crohn's disease ( 21102463)
Interacting Genes		107 interacting genes: ACTB AKT1 APP AR AURKA CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CD44 CDC34 CDKN2A CERKL CHEK2 CLU COL4A2 CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR FKBP8 FLNA FN1 GHET1 GPS1 H1-2 H2BC13 H4-16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IKBKB JADE1 KIF2C KIF3A KLF4 LANCL1 MAP1LC3B MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PIAS4 PLD1 PLD2 POLR2G PPP5C PRDX1 PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TPT1 TRIM28 UBE2D1 UBE2D2 UBE2I UBE2S USP20 USP33 USP9X UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B	239 interacting genes: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ARRDC3 ASB2 ASB4 ASB9 BABAM2 BARD1 BFAR BIK BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 COP1 CRBN CREBBP CRYAB CTNNB1 CUL2 CUL3 DDX58 DTL DTX1 DTX2 DTX3 DTX3L DYRK2 DZIP3 EP300 EPS15 F12 FAF2 FBXL17 FBXL2 FBXO2 FBXO7 FOS FZR1 GADD45A GSK3B H3C1 H4C1 HDAC6 HECW1 HERC2 HERC3 HERC5 HIF1A HSD17B10 HUWE1 ITCH KAT2B KCTD17 KDM2B KLHL13 KLHL2 KLHL9 LNPK LRR1 LRSAM1 LTN1 MAP3K1 MARCHF1 MARCHF2 MARCHF4 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEOX2 MGRN1 MIB1 MID1 MID2 MKNK1 MKRN1 MKRN2 MKRN3 MUL1 NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NONO NQO1 NR1H2 OBI1 OTUB1 OTULIN PELI1 PER2 PJA2 POLL POLM PRKN RABGEF1 RAG1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5A RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF125 RNF126 RNF128 RNF13 RNF130 RNF14 RNF144A RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF182 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 RSAD2 SH3RF1 SHPRH SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF1 SMURF2 SPOP STAM2 STUB1 SUFU TAF1D TBL1X TMEM129 TNFAIP3 TNNT1 TOM1 TOPORS TP53 TRAF2 TRAF4 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM69 TRIM7 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UBTD1 UFM1 UHRF1 UHRF2 UVSSA VHL WWP1 WWP2 XIAP ZNF598 ZNRF1 ZNRF2 ZNRF4
Entrez ID		7428	7321
HPRD ID		01905	04267
Ensembl ID		ENSG00000134086	ENSG00000072401
Uniprot IDs		A0A024R2F2 A0A0S2Z4K1 P40337	A0A024QZJ2 A0A087WW00 P51668
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC	2C4P 2YHO 3OJ4 3PTF 4AP4 4QPL 5FER 5TUT 6D4P
Enriched GO Terms of Interacting Partners?
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