VHL and HSPA8

Data Source:
BioGRID (pull down)

		VHL	HSPA8
Description		von Hippel-Lindau tumor suppressor	heat shock protein family A (Hsp70) member 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Late Endosome Autophagosome Cytosol Plasma Membrane Focal Adhesion Membrane Dendrite Secretory Granule Lumen Melanosome Terminal Bouton Lysosomal Lumen Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Photoreceptor Ribbon Synapse Glycinergic Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Postsynaptic Specialization Membrane Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Ligase-substrate Adaptor Activity	G Protein-coupled Receptor Binding Phosphatidylserine Binding RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Clathrin-uncoating ATPase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Apoptotic Process Post-translational Protein Modification Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	MRNA Splicing, Via Spliceosome Protein Folding Response To Unfolded Protein Neurotransmitter Secretion Cellular Response To Starvation Viral Process Vesicle-mediated Transport Cytokine-mediated Signaling Pathway Regulation Of Protein Stability Cellular Response To Unfolded Protein Protein Refolding Regulation Of Protein-containing Complex Assembly Neutrophil Degranulation Regulation Of MRNA Stability Positive Regulation By Host Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Cofactor-dependent Protein Refolding Regulation Of Cell Cycle Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Late Endosomal Microautophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy Clathrin Coat Disassembly Regulation Of Postsynapse Organization Regulation Of Cellular Response To Heat Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly Slow Axonal Transport
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha SUMOylation of ubiquitinylation proteins Neddylation Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy
Drugs			Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Diseases		Renal cell carcinoma von Hippel-Lindau syndrome Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Postoperative acute renal failure after cardiac surgery ( 30678657) Red cell distribution width ( 32888494)
Interacting Genes		107 interacting genes: ACTB AKT1 APP AR AURKA CAPN7 CAPZB CASR CBR1 CBX1 CBX3 CCNC CCT3 CD44 CDC34 CDKN2A CERKL CHEK2 CLU COL4A2 CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EGLN1 ELOB ELOC EPAS1 EPOR FKBP8 FLNA FN1 GHET1 GPS1 H1-2 H2BC13 H4-16 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HNRNPA2B1 HNRNPD HSF2BP HSPA5 HSPA8 IKBKB JADE1 KIF2C KIF3A KLF4 LANCL1 MAP1LC3B MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PIAS4 PLD1 PLD2 POLR2G PPP5C PRDX1 PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RHOBTB3 RNF139 RPL21 RPL5 RPS15A RWDD3 SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TPT1 TRIM28 UBE2D1 UBE2D2 UBE2I UBE2S USP20 USP33 USP9X UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B	91 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DPP3 DYNLL1 EGFR ENO1 ERBB3 ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 SGTA SIRPA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCAP TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ
Entrez ID		7428	3312
HPRD ID		01905	07205
Ensembl ID		ENSG00000134086	ENSG00000109971
Uniprot IDs		A0A024R2F2 A0A0S2Z4K1 P40337	P11142 Q53HF2 V9HW22
PDB IDs		1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I7Q 6I7R 6R6H 6R7F 6SIS 6ZHC	3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N
Enriched GO Terms of Interacting Partners?
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