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VHL and H4-16
Data Source:
BioGRID
(pull down)
VHL
H4-16
Description
von Hippel-Lindau tumor suppressor
H4 histone 16
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Membrane
Nuclear Chromosome
Chromosome, Telomeric Region
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein-containing Complex
Extracellular Exosome
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Ligase-substrate Adaptor Activity
DNA Binding
RNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Regulation Of Transcription, DNA-templated
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
RDNA Heterochromatin Assembly
Double-strand Break Repair Via Nonhomologous End Joining
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
DNA-templated Transcription, Initiation
Telomere Capping
Telomere Organization
CENP-A Containing Nucleosome Assembly
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Gene Silencing By MiRNA
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
PKMTs methylate histone lysines
HDMs demethylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
Renal cell carcinoma
von Hippel-Lindau syndrome
Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS
Interacting Genes
107 interacting genes:
ACTB
AKT1
APP
AR
AURKA
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CD44
CDC34
CDKN2A
CERKL
CHEK2
CLU
COL4A2
CSNK2A1
CUL2
CUL5
DGKI
DNAJA3
DVL2
E2F1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
FKBP8
FLNA
FN1
GHET1
GPS1
H1-2
H2BC13
H4-16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IKBKB
JADE1
KIF2C
KIF3A
KLF4
LANCL1
MAP1LC3B
MDFI
NCL
NR4A1
NR4A2
NR4A3
PDCD5
PIAS4
PLD1
PLD2
POLR2G
PPP5C
PRDX1
PRKCI
PRMT1
PRMT8
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SARNP
SAT2
SKP2
SLC2A1
SLC3A2
SON
SP1
TPT1
TRIM28
UBE2D1
UBE2D2
UBE2I
UBE2S
USP20
USP33
USP9X
UXT
VAPB
VBP1
YY1AP1
ZNF197
ZNF512B
56 interacting genes:
ANP32A
ARID4A
ASF1A
ASF1B
BRD2
BRD4
BRD7
CBX5
CDY1
COPRS
CREBBP
DAXX
DNTTIP2
EP300
GADD45A
HAT1
HDAC6
HDAC8
HDAC9
ING2
KAT14
KAT2A
KAT2B
KAT5
KAT6A
KMT5A
L3MBTL1
LRWD1
MSL3
NCOA2
NCOA3
NOC2L
NSD1
ORC2
ORC3
ORC4
ORC5
PRMT1
PRMT5
PRMT6
RAG1
RBBP4
RPS6KA5
SAP30
SET
SETDB1
SIAH1
SMARCA5
TAF1A
TCF19
TP53BP1
UBE2I
UCHL5
USP16
VHL
WDR5
Entrez ID
7428
121504
HPRD ID
01905
13662
Ensembl ID
ENSG00000134086
ENSG00000197837
Uniprot IDs
A0A024R2F2
A0A0S2Z4K1
P40337
B2R4R0
P62805
PDB IDs
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
1ZKK
2BQZ
2CV5
2IG0
2KWN
2KWO
2LVM
2QQS
2RJE
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3IJ1
3JPX
3NQJ
3NQU
3O36
3QBY
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
3WA9
3WAA
3WKJ
3WTP
3X1S
3X1T
3X1U
3X1V
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
4M38
4N3W
4N4F
4QUT
4QUU
4QYD
4U9W
4YM5
4YM6
4YY6
4YYD
4YYG
4YYH
4YYI
4YYJ
4YYK
4YYM
4YYN
4Z2M
4Z5T
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5AY8
5B0Y
5B0Z
5B24
5B2I
5B2J
5B31
5B32
5B33
5B40
5BNV
5BNX
5BO0
5C3I
5CPI
5CPJ
5CPK
5FA5
5FFW
5FWE
5GSE
5GSU
5GT0
5GT3
5GTC
5GXQ
5JA4
5JRG
5KDM
5TEG
5X7X
5XF3
5XF4
5XF5
5Y0C
5Y0D
5YE3
5YE4
5Z23
5Z30
5ZBX
5ZGC
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6ACP
6BUZ
6C0W
6E0C
6E0P
6FML
6HKT
6HTS
6INQ
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6JOU
6JR0
6JR1
6K1I
6K1J
6K1K
6KE9
6KVD
6KXV
6L49
6L4A
6L9H
6LA8
6LA9
6LE9
6M3V
6M44
6M4D
6M4G
6M4H
6MLC
6MUO
6MUP
6O1D
6R0C
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6RNY
6RXS
6SE0
6SE6
6SEE
6SEF
6SEG
6T79
6T7A
6T7B
6T7C
6T7D
6T90
6T93
6UPK
6UPL
6USJ
6V92
6VO5
6X59
6X5A
6XJD
6Y5D
6YOV
7A08
7C0M
7JO9
7JOA
Enriched GO Terms of Interacting Partners
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