UBE2D1 and BIRC2

Data Source:
BioGRID (pull down, pull down, pull down, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down)

		UBE2D1	BIRC2
Description		ubiquitin conjugating enzyme E2 D1	baculoviral IAP repeat containing 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	XY Body Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Ubiquitin Binding Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Ubiquitin Protein Ligase Activity FBXO Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Peroxisome Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Polyubiquitination	Protein Polyubiquitination Response To Hypoxia Placenta Development MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Deubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex TICAM1, RIP1-mediated IKK complex recruitment APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Signaling by BMP Downstream TCR signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Ovarian tumor domain proteases CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Apoptotic cleavage of cellular proteins NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS		Brain imaging ( 20100581) Crohn's disease ( 21102463)	Prostate cancer ( 23535732)
Interacting Genes		239 interacting genes: AMFR ANAPC11 ANXA1 ANXA7 AREL1 ARIH1 ARIH2 ARRDC3 ASB2 ASB4 ASB9 BABAM2 BARD1 BFAR BIK BIRC2 BIRC3 BIRC6 BIRC7 BIRC8 BRCA1 BRCC3 BRMS1 C7orf25 CADPS2 CBL CBLC CDK7 CDKN1A CHFR CNOT4 COP1 CRBN CREBBP CRYAB CTNNB1 CUL2 CUL3 DDX58 DTL DTX1 DTX2 DTX3 DTX3L DYRK2 DZIP3 EP300 EPS15 F12 FAF2 FBXL17 FBXL2 FBXO2 FBXO7 FOS FZR1 GADD45A GSK3B H3C1 H4C1 HDAC6 HECW1 HERC2 HERC3 HERC5 HIF1A HSD17B10 HUWE1 ITCH KAT2B KCTD17 KDM2B KLHL13 KLHL2 KLHL9 LNPK LRR1 LRSAM1 LTN1 MAP3K1 MARCHF1 MARCHF2 MARCHF4 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEOX2 MGRN1 MIB1 MID1 MID2 MKNK1 MKRN1 MKRN2 MKRN3 MUL1 NBN NEDD4 NEDD4L NEURL1 NFKBIA NHLRC1 NONO NQO1 NR1H2 OBI1 OTUB1 OTULIN PELI1 PER2 PJA2 POLL POLM PRKN RABGEF1 RAG1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5A RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF125 RNF126 RNF128 RNF13 RNF130 RNF14 RNF144A RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF182 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF6 RNF7 RNF8 RSAD2 SH3RF1 SHPRH SIAH1 SIAH2 SIRT6 SIVA1 SKP1 SMURF1 SMURF2 SPOP STAM2 STUB1 SUFU TAF1D TBL1X TMEM129 TNFAIP3 TNNT1 TOM1 TOPORS TP53 TRAF2 TRAF4 TRAF6 TRAF7 TRAIP TRIM10 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM69 TRIM7 TRIM8 TRIP12 TSC22D1 UBA1 UBA6 UBASH3B UBC UBE3A UBE3C UBE4A UBOX5 UBTD1 UFM1 UHRF1 UHRF2 UVSSA VHL WWP1 WWP2 XIAP ZNF598 ZNRF1 ZNRF2 ZNRF4	75 interacting genes: ABHD17A BIRC5 BLK BMX BOLA1 BOLA2 BOLA2B CASP3 CASP7 CASP9 CBLC CD40 CDC42 CSE1L DIABLO DZIP3 E2F1 EAF2 EIF4E EXOSC5 FBXO7 GAS1 GCC1 GFAP GLMN GSPT1 HSP90B1 HTRA2 IGF2BP1 IKBKE IKBKG JUP KDM1A LNX1 LTBR MAD1L1 MAGEA11 MAP3K2 MAP3K3 NMB NXF1 OTUB1 PACS2 PCSK9 PFN2 PPM1K RAC1 RAF1 RFC5 RHOA RIPK2 RIPK3 RIPK4 RNF181 RUNX1T1 TCAF1 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 TUFT1 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2N UBE2Q2 UBE2S UBE2V1 UBE2W
Entrez ID		7321	329
HPRD ID		04267	03419
Ensembl ID		ENSG00000072401	ENSG00000110330
Uniprot IDs		A0A024QZJ2 A0A087WW00 P51668	Q13490
PDB IDs		2C4P 2YHO 3OJ4 3PTF 4AP4 4QPL 5FER 5TUT 6D4P	1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4KMN 4LGE 4LGU 4MTI 4MU7 5M6N 6EXW 6HPR
Enriched GO Terms of Interacting Partners?
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