TSHB and TSHR

Data Source:
HPRD (in vivo)

		TSHB	TSHR
Description		thyroid stimulating hormone subunit beta	thyroid stimulating hormone receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Hormone Activity	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Anatomical Structure Morphogenesis Hormone-mediated Signaling Pathway Peptide Hormone Processing Response To Vitamin A Response To Estrogen Response To Calcium Ion	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone
Pathways		Glycoprotein hormones Thyroxine biosynthesis Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Thyrotropin alfa
Diseases		Congenital nongoitrous hypothyroidism (CHNG)	Congenital nongoitrous hypothyroidism (CHNG)
GWAS		California verbal learning test score ( 31596458)	Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		2 interacting genes: CGA TSHR	38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB
Entrez ID		7252	7253
HPRD ID		11766	04537
Ensembl ID		ENSG00000134200	ENSG00000165409
Uniprot IDs		P01222	A0A0A0MTJ0 P16473
PDB IDs			1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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