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TSHR and HSPA5
Data Source:
HPRD
(in vivo, in vitro)
TSHR
HSPA5
Description
thyroid stimulating hormone receptor
heat shock protein family A (Hsp70) member 5
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Receptor Complex
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Thyroid-stimulating Hormone Receptor Activity
Protein Binding
G Protein-coupled Peptide Receptor Activity
Signaling Receptor Activity
Protein-containing Complex Binding
Calcium Ion Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Protein Domain Specific Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
Biological Process
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Hormone-mediated Signaling Pathway
Thyroid-stimulating Hormone Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Cellular Response To Glycoprotein
Cellular Response To Thyrotropin-releasing Hormone
Luteolysis
ER Overload Response
Positive Regulation Of Neuron Projection Development
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Neuron Differentiation
Positive Regulation Of Cell Migration
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Posttranslational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Cellular Response To Unfolded Protein
Protein Folding In Endoplasmic Reticulum
Maintenance Of Protein Localization In Endoplasmic Reticulum
Cellular Response To Drug
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Protein Refolding
Cellular Response To Glucose Starvation
Response To Cocaine
Negative Regulation Of Apoptotic Process
Chaperone Cofactor-dependent Protein Refolding
Neuron Apoptotic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Antibiotic
Cellular Response To Calcium Ion
Cellular Response To Manganese Ion
Cellular Response To CAMP
Cellular Response To Interleukin-4
Cellular Response To Gamma Radiation
Stress Response To Metal Ion
Toxin Transport
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Response To Methamphetamine Hydrochloride
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
Hormone ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Thyrotropin alfa
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
Congenital nongoitrous hypothyroidism (CHNG)
GWAS
Graves' disease (
21841780
22922229
)
Hair morphology (
19896111
)
Male sexual orientation (
29217827
)
Maximal oxygen uptake response (
25729143
)
Obstetric antiphospholipid syndrome (
28424481
)
Optic nerve measurement (rim area) (
20395239
)
Smooth-surface caries (
24556642
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Tourette syndrome (
30818990
)
Uric acid levels (
21294900
)
Urinary albumin excretion (
32277301
)
Visceral fat (
22589738
)
Refractive error (
32231278
)
Interacting Genes
38 interacting genes:
ACTB
ADORA1
ADRB2
ASPHD1
BNIP1
CALR
CANX
CD81
CRADD
FLNB
FN1
GNA11
GNA12
GNA13
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GNAS
HNRNPA1
HSPA5
JAK1
JAK2
JPH3
LHCGR
MID1IP1
MOG
PIK3R1
PTDSS1
RABAC1
RUNDC3A
SCRIB
STAT3
SYT1
TMCO3
TMEM119
TSHB
70 interacting genes:
A2M
APC
APOB
BAG3
BCAR1
CASP7
CPT1A
DDX24
DNAJC1
DNAJC10
DNAJC3
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
GRB2
GRIA1
HLA-C
HMGB1
HSPB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
OTUD3
PARK7
PAWR
PCSK7
PRNP
PSME3
PTPN11
PTPRF
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
YWHAB
Entrez ID
7253
3309
HPRD ID
04537
00682
Ensembl ID
ENSG00000165409
ENSG00000044574
Uniprot IDs
A0A0A0MTJ0
P16473
P11021
V9HWB4
PDB IDs
1XUM
2XWT
3G04
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
Enriched GO Terms of Interacting Partners
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