TSHR and JPH3

Data Source:
BioGRID (two hybrid)

		TSHR	JPH3
Description		thyroid stimulating hormone receptor	junctophilin 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex	Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Junctional Membrane Complex
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Molecular_function Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Learning Memory Exploration Behavior Locomotion Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Transport Into Cytosol
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Thyrotropin alfa
Diseases		Congenital nongoitrous hypothyroidism (CHNG)	Core neuroacanthocytosis syndromes, including: Chorea-acanthocytosis (ChAc); McLeod syndrome (MLS); Huntington's disease-like 2 (HDL2); Pantothenate kinase associated neurodegeneration (PKAN)
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Height ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ischemic stroke ( 29531354) Late-onset Alzheimer's disease ( 27770636) Migraine ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Refractive error ( 32231278) Small vessel stroke ( 27997041) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB	7 interacting genes: BGN CCR2 KRTAP10-8 PPP1CA SMAD3 SMO TSHR
Entrez ID		7253	57338
HPRD ID		04537	05589
Ensembl ID		ENSG00000165409	ENSG00000154118
Uniprot IDs		A0A0A0MTJ0 P16473	B4DIC1 F8W9A3 Q8WXH2 Q96HD8
PDB IDs		1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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