TNNI3 and PAPPA

Data Source:
HPRD (in vitro)

		TNNI3	PAPPA
Description		troponin I3, cardiac type	pappalysin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Extracellular Region Extracellular Space
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding Actin Filament Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid
Pathways		Striated Muscle Contraction Ion homeostasis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide	Phenethyl Isothiocyanate
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Platelet count ( 32888494)	Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Metabolite levels ( 23823483) Pulse pressure ( 30224653)
Interacting Genes		19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	10 interacting genes: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3
Entrez ID		7137	5069
HPRD ID		11769	01448
Ensembl ID		ENSG00000129991	ENSG00000182752
Uniprot IDs		P19429 Q6FGX2	B4DTA8 Q13219 Q7Z613
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI
Enriched GO Terms of Interacting Partners?
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