PAPPA and IGFBP4

Data Source:
HPRD (in vitro)

		PAPPA	IGFBP4
Description		pappalysin 1	insulin like growth factor binding protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid	Regulation Of Cell Growth Inflammatory Response Signal Transduction Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Metabolite levels ( 23823483) Pulse pressure ( 30224653)	Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		10 interacting genes: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	8 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A PAPPA SUV39H1 TF
Entrez ID		5069	3487
HPRD ID		01448	00900
Ensembl ID		ENSG00000182752	ENSG00000141753
Uniprot IDs		B4DTA8 Q13219 Q7Z613	A0A024R1U8 P22692
PDB IDs			1WQJ 2DSP 2DSQ 2DSR
Enriched GO Terms of Interacting Partners?
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