PAPPA and PRG2

Data Source:
HPRD (in vitro)

		PAPPA	PRG2
Description		pappalysin 1	proteoglycan 2, pro eosinophil major basic protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Transport Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Proteolysis Female Pregnancy Response To Follicle-stimulating Hormone Cellular Protein Metabolic Process Response To Glucocorticoid	Defense Response To Bacterium Neutrophil Degranulation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Neutrophil degranulation
Drugs		Phenethyl Isothiocyanate	Sargramostim Chymopapain
Diseases
GWAS		Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Conotruncal heart defects ( 24800985) Heel bone mineral density ( 28869591) Height ( 28552196 20881960 18391950) Metabolite levels ( 23823483) Pulse pressure ( 30224653)	Crohn's disease ( 22412388) Glucose homeostasis traits ( 25524916)
Interacting Genes		10 interacting genes: ATF7IP C3 IGFBP4 PLG PRG2 SKIL SMAD2 SMAD3 SMAD9 TNNI3	7 interacting genes: AGT AKT1 CHD3 CSF2 PAPPA PRKCZ RBM48
Entrez ID		5069	5553
HPRD ID		01448	09283
Ensembl ID		ENSG00000182752	ENSG00000186652
Uniprot IDs		B4DTA8 Q13219 Q7Z613	P13727
PDB IDs			1H8U 2BRS 4QXX
Enriched GO Terms of Interacting Partners?
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