CLEC7A and OCLN

Data Source:
BioGRID (two hybrid)

		CLEC7A	OCLN
Description		C-type lectin domain containing 7A	occludin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction
	Molecular Function	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Metal Ion Binding	Protein Binding Protein Domain Specific Binding
	Biological Process	Leukocyte Activation Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Respiratory Burst Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of Glucose Import Protein-containing Complex Assembly Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Tumor Necrosis Factor Positive Regulation Of Wound Healing Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Bicellular Tight Junction Assembly
Pathways		CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling	Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)	Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS			Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)
Interacting Genes		47 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1	11 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 PTPN2 SNW1 SYNE4 TJP1 TNFAIP3 ULK1
Entrez ID		64581	100506658
HPRD ID		08396
Ensembl ID		ENSG00000172243	ENSG00000197822
Uniprot IDs		A0A024RAN9 A0A0S2Z5Q1 Q68D78 Q9BXN2	A8K3T2 Q16625
PDB IDs			1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?
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