OCLN and TJP1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		OCLN	TJP1
Description		occludin	tight junction protein 1
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GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of Glucose Import Protein-containing Complex Assembly Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Tumor Necrosis Factor Positive Regulation Of Wound Healing Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Bicellular Tight Junction Assembly	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Hippo Signaling Maintenance Of Blood-brain Barrier Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Actin Cytoskeleton Reorganization Regulation Of Bicellular Tight Junction Assembly
Pathways		Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases		Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS		Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)	Central corneal thickness ( 32528159 31798171 29760442 30894546) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Interacting Genes		11 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 PTPN2 SNW1 SYNE4 TJP1 TNFAIP3 ULK1	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 OCLN PEA15 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		100506658	7082
HPRD ID			03002
Ensembl ID		ENSG00000197822	ENSG00000104067
Uniprot IDs		A8K3T2 Q16625	A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157 Q6MZU1
PDB IDs		1WPA 1XAW 3G7C	2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?
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