OCLN and ULK1

Data Source:
BioGRID (two hybrid)

		OCLN	ULK1
Description		occludin	unc-51 like autophagy activating kinase 1
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GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction	Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Guanyl-nucleotide Exchange Factor Complex Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of Glucose Import Protein-containing Complex Assembly Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Tumor Necrosis Factor Positive Regulation Of Wound Healing Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Bicellular Tight Junction Assembly	Protein Phosphorylation Autophagy Signal Transduction Protein Localization Positive Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Axon Extension Positive Regulation By Symbiont Of Host Autophagy Positive Regulation Of Autophagosome Assembly
Pathways		Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions	Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy
Drugs			Fostamatinib
Diseases		Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS		Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)	Body mass index ( 26426971) Mercury levels ( 26025379)
Interacting Genes		11 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 PTPN2 SNW1 SYNE4 TJP1 TNFAIP3 ULK1	19 interacting genes: ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAPK14 MBP MEFV MUL1 NEDD4L OCLN PPP1CA PRKAA1 SDCBP SMCR8 SYNGAP1 UBC USP20
Entrez ID		100506658	8408
HPRD ID			11933
Ensembl ID		ENSG00000197822	ENSG00000177169
Uniprot IDs		A8K3T2 Q16625	O75385
PDB IDs		1WPA 1XAW 3G7C	4WNO 4WNP 5CI7 6HYO 6MNH 6QAS
Enriched GO Terms of Interacting Partners?
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