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TRPV4 and YES1
Data Source:
HPRD
(in vivo, in vitro)
TRPV4
YES1
Description
transient receptor potential cation channel subfamily V member 4
YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum
Cytoplasmic Microtubule
Plasma Membrane
Integral Component Of Plasma Membrane
Adherens Junction
Focal Adhesion
Cilium
Integral Component Of Membrane
Apical Plasma Membrane
Lamellipodium
Filopodium
Growth Cone
Cortical Actin Cytoskeleton
Ruffle Membrane
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Plasma Membrane
Focal Adhesion
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Extracellular Exosome
Molecular Function
Actin Binding
Protein Kinase C Binding
Ion Channel Activity
Cation Channel Activity
Calcium Channel Activity
Protein Binding
Calmodulin Binding
ATP Binding
Microtubule Binding
Lipid Binding
Stretch-activated, Cation-selective, Calcium Channel Activity
Protein Kinase Binding
SH2 Domain Binding
Identical Protein Binding
Alpha-tubulin Binding
Metal Ion Binding
Beta-tubulin Binding
Actin Filament Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Enzyme Binding
Ion Channel Binding
Biological Process
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Cell Volume Homeostasis
Actin Filament Organization
Cell-cell Junction Assembly
Positive Regulation Of Cytosolic Calcium Ion Concentration
Osmosensory Signaling Pathway
Response To Mechanical Stimulus
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Microtubule Depolymerization
Actin Cytoskeleton Reorganization
Cellular Response To Heat
Positive Regulation Of Vascular Permeability
Cortical Microtubule Organization
Microtubule Polymerization
Multicellular Organismal Water Homeostasis
Cartilage Development Involved In Endochondral Bone Morphogenesis
Calcium Ion Import
Calcium Ion Transmembrane Transport
Cellular Response To Osmotic Stress
Cellular Hypotonic Response
Blood Vessel Endothelial Cell Delamination
Calcium Ion Import Across Plasma Membrane
Calcium Ion Import Into Cytosol
Cellular Protein Modification Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Differentiation
T Cell Costimulation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Vascular Permeability
Innate Immune Response
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Pathways
TRP channels
Signaling by ERBB2
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Drugs
Cannabidiol
Butamben
Medical Cannabis
Nabiximols
Dasatinib
Fostamatinib
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia
TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC)
Distal hereditary motor neuropathies (dHMN)
GWAS
Creatinine levels (
29403010
)
Glomerular filtration rate (
29403010
)
Diastolic blood pressure (
29403010
30487518
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Pulmonary function in asthmatics (
23541324
)
Pursuit maintenance gain (
29064472
)
Systolic blood pressure (
30224653
29403010
30487518
30578418
)
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) (
31794020
)
Interacting Genes
14 interacting genes:
CALM1
FYN
HCK
ITCH
KRIT1
LCK
LYN
MAP7
OS9
PACSIN1
PACSIN2
PACSIN3
SRC
YES1
98 interacting genes:
ADAM12
ADAM15
AMOTL2
AR
BCAR1
BECN1
BICD2
C1orf94
CARD9
CBL
CBLB
CBLC
CCDC33
CD2AP
CD36
CD46
CDH1
CDKN1B
CEP57L1
CEP83
CHMP1A
CPSF6
CRKL
CSF1R
DDIT4L
DENND2C
DES
DLG4
DOK1
DOK2
DTX3
DVL2
EFS
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FLACC1
FLT1
FUNDC1
FXR1
FXR2
GAB1
GAS8
GFAP
GP6
IKZF3
ITGB4
JAK2
JAKMIP1
KDR
KHDRBS1
KIT
LASP1
LIN7C
MET
MST1R
NEDD4
NIF3L1
NPHS1
OGT
PAK2
PDCD6IP
PDGFRB
PECAM1
PICK1
PIK3R3
PTEN
PTK2
PTPRE
PXN
RASA1
RPL10
SH3GLB2
SKAP2
SLC9A3R1
SOCS2
SOCS3
SOCS7
SPRR2A
SSBP3
STAP2
THAP1
TNK2
TP53BP2
TRAF2
TRAF6
TRIM5
TRPV4
TSGA10IP
TYRO3
ZBTB8A
ZC2HC1A
ZNF438
ZNF512B
Entrez ID
59341
7525
HPRD ID
05667
01285
Ensembl ID
ENSG00000111199
ENSG00000176105
Uniprot IDs
Q9HBA0
P07947
PDB IDs
4DX1
4DX2
2HDA
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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